And lastly, clonidine boosts neuraxial opioids and, together with fentanyl, interacts within an additive method, which often can reduce the dose of every ingredient by 60% for postoperative analgesia. Clonidine treats superior blood pressure level by stimulating α2 receptors inside the brainstem, which decreases peripheral vascular resistance, decreasing hypertension. https://www.proleviate.com/post/the-new-pain-killer-conolidine